000013960 001__ 13960
000013960 005__ 20161115094006.0
000013960 04107 $$aeng
000013960 046__ $$k2016-08-21
000013960 100__ $$aShi, Xinghua
000013960 24500 $$aRotation-facilitated rapid transport of nanorods in mucosal tissues

000013960 24630 $$n24.$$p24th International Congress of Theoretical and Applied Mechanics - Book of Papers
000013960 260__ $$bInternational Union of Theoretical and Applied Mechanics, 2016
000013960 506__ $$arestricted
000013960 520__ $$2eng$$aMucus is a viscoelastic gel layer that typically protects exposed surfaces of the gastrointestinal (GI) tract, lung airways, and other mucosal tissues. Particles targeted to these tissues can be efficiently trapped and removed by mucus, thereby limiting the effectiveness of such drug delivery systems. In this study, we experimentally and theoretically demonstrated that cylindrical nanoparticles (NPs), such as mesoporous silica nanorods, have superior transport and trafficking capability in mucus compared with spheres of the same chemistry. The higher diffusivity of nanorods leads to deeper mucus penetration and a longer retention time in the GI tract than that of their spherical counterparts. Molecular simulations and stimulated emission of depletion (STED) microscopy revealed that this anomalous phenomenon can be attributed to the rotational dynamics of the NPs facilitated by the mucin fibers and the shear flow. These findings shed new light on the shape design of NPbased drug delivery systems targeted to mucosal and tumor sites that possess a fibrous structure/porous medium.

000013960 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000013960 653__ $$a

000013960 7112_ $$a24th International Congress of Theoretical and Applied Mechanics$$cMontreal (CA)$$d2016-08-21 / 2016-08-26$$gICTAM2016
000013960 720__ $$aShi, Xinghua
000013960 8560_ $$ffischerc@itam.cas.cz
000013960 8564_ $$s98344$$uhttps://invenio.itam.cas.cz/record/13960/files/PO.FM11-1.11.71.pdf$$yOriginal version of the author's contribution as presented on CD, XMLout( page 1244, code PO.FM11-1.11.71).
000013960 962__ $$r13812
000013960 980__ $$aPAPER