000014401 001__ 14401
000014401 005__ 20161115100150.0
000014401 04107 $$aeng
000014401 046__ $$k2016-08-21
000014401 100__ $$aAtwell, Scott
000014401 24500 $$aMicrocirculation of red blood cells for two major genetic diseases

000014401 24630 $$n24.$$p24th International Congress of Theoretical and Applied Mechanics - Book of Papers
000014401 260__ $$bInternational Union of Theoretical and Applied Mechanics, 2016
000014401 506__ $$arestricted
000014401 520__ $$2eng$$aSickle Cell Anaemia and Hereditary Spherocytosis are genetic hematological disorders in which red blood cell rigidity is increased. These changes result in problems of RBC circulation in narrow capillaries and through the thin slits of splenic sinusoids - both situations where the RBCs may be subject to very strong deformations. Here, we first show that even in presence of oxygen most RBCs from sickle cell anemia patients have an impaired motion when submitted to a shear flow at low shear rate. We then observe the passage of sickle RBCs, spherocytes and healthy RBCs through slits mimicking interendothelial slits within the spleen. Their difference in terms of transit time, trapped cell ratio, lysis ratio and RBC recovery time are quantitatively determined.

000014401 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000014401 653__ $$a

000014401 7112_ $$a24th International Congress of Theoretical and Applied Mechanics$$cMontreal (CA)$$d2016-08-21 / 2016-08-26$$gICTAM2016
000014401 720__ $$aAtwell, Scott
000014401 8560_ $$ffischerc@itam.cas.cz
000014401 8564_ $$s180621$$uhttps://invenio.itam.cas.cz/record/14401/files/TS.FM01-1.02.pdf$$yOriginal version of the author's contribution as presented on CD,  page 410, code TS.FM01-1.02
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000014401 962__ $$r13812
000014401 980__ $$aPAPER