000014405 001__ 14405
000014405 005__ 20161115100150.0
000014405 04107 $$aeng
000014405 046__ $$k2016-08-21
000014405 100__ $$aQi, Qin
000014405 24500 $$aA coarse-grained theory to predict particle margination and migration in blood suspensions

000014405 24630 $$n24.$$p24th International Congress of Theoretical and Applied Mechanics - Book of Papers
000014405 260__ $$bInternational Union of Theoretical and Applied Mechanics, 2016
000014405 506__ $$arestricted
000014405 520__ $$2eng$$aThe inhomogeneous distribution of red blood cells and platelets normal to the flow direction plays a significant role in hemostasis, drug delivery and microfluidics. In this paper, we develop a coarse-grained theory to predict these distributions in pressure-driven channel flow at zero Reynolds number and compare them to experiments and simulations. We demonstrate that the balance between the deformability-induced lift force and shear-induced diffusion results in a red blood cells’ peak concentration at the channel center and leaves a cell-free or “Fahraeus-Lindqvist” layer near the walls. On the other hand, in the absence of a lift force, platelets have excess concentration in the cell-free layer due to cell-platelet collisions. We also include in the model the process of platelets forming bonds with VWF-coated surfaces, linking cell migration and platelet margination to bleeding events. We thus describe the role of hematocrit in platelet activity as found in our associated experimental results.

000014405 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000014405 653__ $$a

000014405 7112_ $$a24th International Congress of Theoretical and Applied Mechanics$$cMontreal (CA)$$d2016-08-21 / 2016-08-26$$gICTAM2016
000014405 720__ $$aQi, Qin
000014405 8560_ $$ffischerc@itam.cas.cz
000014405 8564_ $$s66255$$uhttps://invenio.itam.cas.cz/record/14405/files/TS.FM01-1.06.pdf$$yOriginal version of the author's contribution as presented on CD,  page 418, code TS.FM01-1.06
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000014405 962__ $$r13812
000014405 980__ $$aPAPER