000014639 001__ 14639
000014639 005__ 20161115100157.0
000014639 04107 $$aeng
000014639 046__ $$k2016-08-21
000014639 100__ $$aShelley, Michael
000014639 24500 $$aFluid-structure interactions in cellular biophysics (INVITED)

000014639 24630 $$n24.$$p24th International Congress of Theoretical and Applied Mechanics - Book of Papers
000014639 260__ $$bInternational Union of Theoretical and Applied Mechanics, 2016
000014639 506__ $$arestricted
000014639 520__ $$2eng$$aThe cellular cytoskeleton is an assembly of microscopic filaments and molecular motors, and is the machinery for performing many cellular processes vital to life such as mitosis and cell division. Despite its critical role, important aspects of cytoskeletal mechanics remain poorly understood, particularly how the interactions of microscopic cytoskeletal elements — filaments and motor-proteins — with each other and the cellular cytoplasm relate to observed larger-scale behavior. One reason for this lack of understanding is the complexity of the fluid-structure interactions involved — mitosis and chromosome segregation can involve hundreds to tens-of-thousands of microtubules — and, when modeling, the difficulty in determining the key actors driving the phenomena. I will discuss recent advances in our theoretical understanding of some important cytoskeletally-driven processes, achieved partly through the development of highly efficient and flexible numerical methods for resolving and evolving large assemblies of microtubules, and partly through carefill combinations of experimental observation and biophysical modeling.

000014639 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000014639 653__ $$a

000014639 7112_ $$a24th International Congress of Theoretical and Applied Mechanics$$cMontreal (CA)$$d2016-08-21 / 2016-08-26$$gICTAM2016
000014639 720__ $$aShelley, Michael
000014639 8560_ $$ffischerc@itam.cas.cz
000014639 8564_ $$s169529$$uhttps://invenio.itam.cas.cz/record/14639/files/TS.FM10-1.05.pdf$$yOriginal version of the author's contribution as presented on CD,  page 1148, code TS.FM10-1.05
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000014639 962__ $$r13812
000014639 980__ $$aPAPER