000014661 001__ 14661
000014661 005__ 20161115100158.0
000014661 04107 $$aeng
000014661 046__ $$k2016-08-21
000014661 100__ $$aNeild, Adrian
000014661 24500 $$aUltrasonic Force Potential Wells for Trapping Arrays of Single Cells - One Cell Per Well (OCPW)

000014661 24630 $$n24.$$p24th International Congress of Theoretical and Applied Mechanics - Book of Papers
000014661 260__ $$bInternational Union of Theoretical and Applied Mechanics, 2016
000014661 506__ $$arestricted
000014661 520__ $$2eng$$aSingle cell analysis enables the study of cellular activity and parameters at an individual, rather than population-average basis. This is made possible by retaining cells so that temporal data can be accessed. In contrast to previous capture approaches utilising mechanical traps, we present an ultrasonic method to capture and release spatially separated cells on demand, with potential for population screening and analysis. The transition from manipulation of particles in groups, which is routinely performed using ultrasound, to individuals requires the reduction of ultrasonic wavelength, but it also introduces a unique physical situation. This arises from the two key forces present: the acoustic radiation force and Bjerknes forces. The former collects particles at defined locations within the sound field, whereas the latter acts to coagulate particles. For collection of individual particles the former is beneficial, the later a hindrance; we show that over a defined range of parameters single particle and cell capture is possible.

000014661 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000014661 653__ $$a

000014661 7112_ $$a24th International Congress of Theoretical and Applied Mechanics$$cMontreal (CA)$$d2016-08-21 / 2016-08-26$$gICTAM2016
000014661 720__ $$aNeild, Adrian
000014661 8560_ $$ffischerc@itam.cas.cz
000014661 8564_ $$s180397$$uhttps://invenio.itam.cas.cz/record/14661/files/TS.FM11-1.06.pdf$$yOriginal version of the author's contribution as presented on CD,  page 1202, code TS.FM11-1.06
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000014661 962__ $$r13812
000014661 980__ $$aPAPER