000014663 001__ 14663
000014663 005__ 20161115100158.0
000014663 04107 $$aeng
000014663 046__ $$k2016-08-21
000014663 100__ $$aKiani, Mohammad
000014663 24500 $$aA biomimetic microfluid assay for rapid screening of anti- inflammatory drugs (INVITED)

000014663 24630 $$n24.$$p24th International Congress of Theoretical and Applied Mechanics - Book of Papers
000014663 260__ $$bInternational Union of Theoretical and Applied Mechanics, 2016
000014663 506__ $$arestricted
000014663 520__ $$2eng$$aAlmost all drugs recently developed in animal models to treat inflammatory disease have failed in clinical trials. There is therefore a significant need for rapid screening of anti-inflammatory drugs before they are tested for safety, efficacy and toxicity in expensive and time consuming large animal models and eventually human trials. We have developed and validated a novel biomimetic microfluidic assay (bMFA) that reproduces the entire leukocyte adhesion cascade in a physiologically realistic three-dimensional environment using human cells and allows for rapid screening of potential therapeutics. Protein Kinase C- delta (PKCS TAT) inhibitor represents a new class of anti-inflammatory drug and we have used bMFA to show the potentially therapeutic effects of this novel drug on human neutrophil-endothelial interactions.

000014663 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000014663 653__ $$a

000014663 7112_ $$a24th International Congress of Theoretical and Applied Mechanics$$cMontreal (CA)$$d2016-08-21 / 2016-08-26$$gICTAM2016
000014663 720__ $$aKiani, Mohammad
000014663 8560_ $$ffischerc@itam.cas.cz
000014663 8564_ $$s176813$$uhttps://invenio.itam.cas.cz/record/14663/files/TS.FM11-2.02.pdf$$yOriginal version of the author's contribution as presented on CD,  page 1206, code TS.FM11-2.02
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000014663 962__ $$r13812
000014663 980__ $$aPAPER