000014978 001__ 14978
000014978 005__ 20161115100208.0
000014978 04107 $$aeng
000014978 046__ $$k2016-08-21
000014978 100__ $$aPerkins, Noel, C
000014978 24500 $$aSimulating nonlinear dynamical transitions of single molecule DNA (INVITED)

000014978 24630 $$n24.$$p24th International Congress of Theoretical and Applied Mechanics - Book of Papers
000014978 260__ $$bInternational Union of Theoretical and Applied Mechanics, 2016
000014978 506__ $$arestricted
000014978 520__ $$2eng$$aThe dynamics of DNA molecules play essential roles in the life cycle of cells. Large dynamical transitions in the conformations of single DNA molecules are required for many cellular functions including, for example, DNA transcription, replication and repair. This paper summarizes how dynamical transitions of DNA can be simulated using a nonlinear rod theory that captures the nonlinear bending and twisting of the molecule on long length/time scales. The resulting numerical solutions describe conformational changes of DNA in the context of two examples; namely 1) the dynamic relaxation of DNA supercoils induced by enzymes, and 2) the dynamic ejection of DNA from viruses during host infection.

000014978 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000014978 653__ $$a

000014978 7112_ $$a24th International Congress of Theoretical and Applied Mechanics$$cMontreal (CA)$$d2016-08-21 / 2016-08-26$$gICTAM2016
000014978 720__ $$aPerkins, Noel, C
000014978 8560_ $$ffischerc@itam.cas.cz
000014978 8564_ $$s153729$$uhttps://invenio.itam.cas.cz/record/14978/files/TS.MS04-1.01.pdf$$yOriginal version of the author's contribution as presented on CD,  page 102, code TS.MS04-1.01
.
000014978 962__ $$r13812
000014978 980__ $$aPAPER