000015032 001__ 15032
000015032 005__ 20161115100209.0
000015032 04107 $$aeng
000015032 046__ $$k2016-08-21
000015032 100__ $$aSafran, Samuel
000015032 24500 $$aMechanical synchronization of active beating within and between cardiomyocytes

000015032 24630 $$n24.$$p24th International Congress of Theoretical and Applied Mechanics - Book of Papers
000015032 260__ $$bInternational Union of Theoretical and Applied Mechanics, 2016
000015032 506__ $$arestricted
000015032 520__ $$2eng$$aWe present theoretical models and predictions of how mechanics due to elastic interactions in actively beating heart cells can lead to synchronization of beating both within single cells and between nearby cells. Our research is motivated by recent experiments that show a correlation between the registry of adjacent muscle fibers and the beating strain of a single, embryonic cardiomyocyte and others that show how  ...  of a nearby heart cell. The theory is generic and analytical in nature and focuses on the role of elastically mediated interactions of oscillating, active force dipoles in these cells. For the single cell, the theory successfully maps the registry data to the strain data. Similar ideas are used to predict the conditions under which an oscillating mechanical probe will or will not  ...  Experiments on single, embryonic cardiomyocytes [1] show that both striation, an indication of the structural registry in muscle fibers, as well as the contractile strains produced by beating cardiac muscle cells, can be optimized by substrate stiffness. We show theoretically how the substrate rigidity dependence of the registry data can be mapped onto that of the strain measurements. The elasticity-mediated structural registry is determined [2] including both the elastic interactions of neighboring, actively contractile acto-myosin units as well as the noise inherent in biological systems. By assuming that structurally registered myofibrils also tend to beat in phase, we explain the observed dependence of both structural striation and beating strain measurements of embryonic heart muscle cells on substrate stiffness in a unified manner. The agreement of our ideas with experiment suggests that the correlated beating of heart cells may be limited by the structural registry of the myofibrils which in turn is regulated by their elastic environment.

000015032 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000015032 653__ $$a

000015032 7112_ $$a24th International Congress of Theoretical and Applied Mechanics$$cMontreal (CA)$$d2016-08-21 / 2016-08-26$$gICTAM2016
000015032 720__ $$aSafran, Samuel
000015032 8560_ $$ffischerc@itam.cas.cz
000015032 8564_ $$s162087$$uhttps://invenio.itam.cas.cz/record/15032/files/TS.MS05-2.01.pdf$$yOriginal version of the author's contribution as presented on CD,  page 252, code TS.MS05-2.01
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000015032 962__ $$r13812
000015032 980__ $$aPAPER