000015039 001__ 15039
000015039 005__ 20161115100209.0
000015039 04107 $$aeng
000015039 046__ $$k2016-08-21
000015039 100__ $$aPurohit, Prashant
000015039 24500 $$aMembrane Tension Controls Kinetics of Neuron Growth

000015039 24630 $$n24.$$p24th International Congress of Theoretical and Applied Mechanics - Book of Papers
000015039 260__ $$bInternational Union of Theoretical and Applied Mechanics, 2016
000015039 506__ $$arestricted
000015039 520__ $$2eng$$aIn the first phase of axon growth, axons sprout from neuron bodies and are extended by the pull of the migrating growth cones towards their targets. Thereafter, a second phase of axon growth, called stretch growth, ensues as the mechanical forces from the growth of the animal induce rapid extension of the nerves. Here we propose a mathematical model for stretch growth of axon tracts in which the rate of production of proteins required for growth is dependent on the membrane tension. We show that there is a length dependent maximum stretching rate that an axon can sustain without disconnection, and that axon length is increased near the cell body. Our model also predicts that the diameter of an axon subjected to stretch growth must increase. Our results could inform better design of stretch growth protocols to create transplantable axon tracts to repair the nervous system.

000015039 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000015039 653__ $$a

000015039 7112_ $$a24th International Congress of Theoretical and Applied Mechanics$$cMontreal (CA)$$d2016-08-21 / 2016-08-26$$gICTAM2016
000015039 720__ $$aPurohit, Prashant
000015039 8560_ $$ffischerc@itam.cas.cz
000015039 8564_ $$s143179$$uhttps://invenio.itam.cas.cz/record/15039/files/TS.MS05-3.02.pdf$$yOriginal version of the author's contribution as presented on CD,  page 266, code TS.MS05-3.02
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000015039 962__ $$r13812
000015039 980__ $$aPAPER