000015090 001__ 15090
000015090 005__ 20161115100211.0
000015090 04107 $$aeng
000015090 046__ $$k2016-08-21
000015090 100__ $$aDeshpande, Vikram
000015090 24500 $$aFluctuations in experiments of cells on substrates (INVITED)

000015090 24630 $$n24.$$p24th International Congress of Theoretical and Applied Mechanics - Book of Papers
000015090 260__ $$bInternational Union of Theoretical and Applied Mechanics, 2016
000015090 506__ $$arestricted
000015090 520__ $$2eng$$aWe present a statistical mechanics framework to model the inherent variability observed in experiments of cells on a range of engineered substrates. The framework comprises two components. First, the probability of observing the cell in a particular state is estimated in terms of the free-energy of that state by invoking the concept of maximising Gibbs entropy. Second, a cytoskeletal protein model is presented for this free-energy of a given state. Predictions using this framework are discussed for a range of experimentally observed phenomena. These include: (i) the spreading of cells as a function of the stiffness and the substrate; (ii) durotaxis whereby cells tends to migrate guided by rigidity gradients on substrates and (iii) differentiation of stem cells guided by the stiffness of substrates.

000015090 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000015090 653__ $$a

000015090 7112_ $$a24th International Congress of Theoretical and Applied Mechanics$$cMontreal (CA)$$d2016-08-21 / 2016-08-26$$gICTAM2016
000015090 720__ $$aDeshpande, Vikram
000015090 8560_ $$ffischerc@itam.cas.cz
000015090 8564_ $$s231309$$uhttps://invenio.itam.cas.cz/record/15090/files/TS.SM01-2.01.pdf$$yOriginal version of the author's contribution as presented on CD,  page 1668, code TS.SM01-2.01
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000015090 962__ $$r13812
000015090 980__ $$aPAPER