000015095 001__ 15095
000015095 005__ 20161115100211.0
000015095 04107 $$aeng
000015095 046__ $$k2016-08-21
000015095 100__ $$aBao, Gang
000015095 24500 $$aForce-induced internalization of magnetic nanoparticles for drug delivery and cell tracking

000015095 24630 $$n24.$$p24th International Congress of Theoretical and Applied Mechanics - Book of Papers
000015095 260__ $$bInternational Union of Theoretical and Applied Mechanics, 2016
000015095 506__ $$arestricted
000015095 520__ $$2eng$$aWe have systematically studied the use of applied magnetic force to facilitate the cellular internalization of magnetic nanoparticles. The magnetic nanoparticles have uniform core sizes and coated with phospholipid-PEG. We investigated the pathway of nanoparticle internalization into different cell types under an applied magnetic field and determined the dependence of cellular uptake on nanoparticle size and concentration, substrate stiffness, temperature, and changes of the cytoskeletal structure. Our results shed light on force-induced endocytosis of nanoparticles and provide a means to remotely control vascular permeability, thus having the potential to shift the paradigm of targeted drug delivery and open up new opportunities for the application of nanotherapeutics.

000015095 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000015095 653__ $$a

000015095 7112_ $$a24th International Congress of Theoretical and Applied Mechanics$$cMontreal (CA)$$d2016-08-21 / 2016-08-26$$gICTAM2016
000015095 720__ $$aBao, Gang
000015095 8560_ $$ffischerc@itam.cas.cz
000015095 8564_ $$s168341$$uhttps://invenio.itam.cas.cz/record/15095/files/TS.SM01-2.06.pdf$$yOriginal version of the author's contribution as presented on CD,  page 1678, code TS.SM01-2.06
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000015095 962__ $$r13812
000015095 980__ $$aPAPER