000015102 001__ 15102
000015102 005__ 20161115100211.0
000015102 04107 $$aeng
000015102 046__ $$k2016-08-21
000015102 100__ $$aSpector, Alexander
000015102 24500 $$aMechanics of stem cell myogenesis

000015102 24630 $$n24.$$p24th International Congress of Theoretical and Applied Mechanics - Book of Papers
000015102 260__ $$bInternational Union of Theoretical and Applied Mechanics, 2016
000015102 506__ $$arestricted
000015102 520__ $$2eng$$aMyo genesis of stem cells is the process of their conversion into skeletal muscle cells. The mechanical factors play a key role in this process, and they can be used to maximize the stem cell myogenic output. Our goal here is a better understanding and use of this effect. We interpret stem cell myogenesis as a progression through several key stages where each of them is characterized by the expression of specific proteins (myogenic factors). The cell stage-to-stage progression is affected by the magnitude and time course of the applied strain through the intracellular signalling. The model of this mechanism is described in terms of nonlinear ODEs and applied to the analysis of stem cell myogenesis under the action of cyclic uniaxial strain The model parameters are adjusted based on a parallel experiment, and the results are used for the optimization of the amplitude, frequency, and duration of the applied strain.

000015102 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000015102 653__ $$a

000015102 7112_ $$a24th International Congress of Theoretical and Applied Mechanics$$cMontreal (CA)$$d2016-08-21 / 2016-08-26$$gICTAM2016
000015102 720__ $$aSpector, Alexander
000015102 8560_ $$ffischerc@itam.cas.cz
000015102 8564_ $$s185584$$uhttps://invenio.itam.cas.cz/record/15102/files/TS.SM01-4.02.pdf$$yOriginal version of the author's contribution as presented on CD,  page 1689, code TS.SM01-4.02
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000015102 962__ $$r13812
000015102 980__ $$aPAPER