000001551 001__ 1551
000001551 005__ 20141118153503.0
000001551 04107 $$acze
000001551 046__ $$k2003-05-12
000001551 100__ $$aPásek, M.
000001551 24500 $$aQuantitative modelling of effect of transverse-axial tubular system on electrical activity of cardiac cells: development of model II

000001551 24630 $$n9.$$pEngineering Mechanics 2003
000001551 260__ $$bInstitute of Theoretical and Applied Mechanics AS CR, Prague
000001551 506__ $$arestricted
000001551 520__ $$2eng$$aIn this work, we present a new version of cardiac ventricular cell model incorporating the transverse - axial tubular system. The improvements include reformulated description of L-type Ca2+ channel, of Ca2+ induced Ca2+ release from sarcoplasmic reticulum, of intracellular Ca2+ buffering and incorporation of potassium currents Ito, IK(Na) and IK(ATP). In comparison with the previous model (Pásek et al., 2002), the steady state simulations revealed more profound changes of tubular ionic concentration (12.8 % for Ca2+ and 4.7 % for K+ at 1 Hz). The refined model will be used for more exact quantitative exploration of the effect of transverse - axial tubular system on cellular electrical activity and excitation - contraction coupling.

000001551 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000001551 653__ $$a

000001551 7112_ $$aEngineering Mechanics 2003$$cSvratka (CZ)$$d2003-05-12 / 2003-05-15$$gEM2003
000001551 720__ $$aPásek, M.$$iŠimurda, J.$$iChristé, G.
000001551 8560_ $$ffischerc@itam.cas.cz
000001551 8564_ $$s248715$$uhttps://invenio.itam.cas.cz/record/1551/files/290-Michal-Pasek-PT.pdf$$y
             Original version of the author's contribution as presented on CD, BIO.
            
000001551 962__ $$r971
000001551 980__ $$aPAPER