000015990 001__ 15990
000015990 005__ 20161115135335.0
000015990 04107 $$aeng
000015990 046__ $$k2013-06-12
000015990 100__ $$aSkatulla, S.
000015990 24500 $$aA Computational Study of the Injection Therapy for Myocardial Infarction During the Necrotic Stage

000015990 24630 $$n34.$$pComputational Methods in Structural Dynamics and Earhquake Engineering
000015990 260__ $$bNational Technical University of Athens, 2013
000015990 506__ $$arestricted
000015990 520__ $$2eng$$aMyocardial infarction is an increasing health problem worldwide. Due to an undersupply of blood, the cardiomyocytes in the affected region permanently lose their ability to contract. This in turn gradually weakens the overall heart function. A new therapeutic approach based on the injection of a gel into the infarcted area aims to support the healing and to inhibit adverse re-modelling that can lead to heart failure. A computational model is the basis for obtaining a better understanding of the heart mechanics, in particular, how myocardial infarction and gel injections affect its pumping performance. A strain invariant based stored energy function is proposed to account for the passive mechanical behaviour. The active contraction is represented by the Guccione model [1]. To incorporate injections an additive homogenization approach is introduced. The injectate has been characterized mechanically by indentation tests. As a numerical framework we are using the in-house code SESKA which is based on the Element-Free Galerkin method. The main focus of this contribution is to principally investigate how gel injections influence the mechanics and performance of the left ventricle during a full heart beat, i.e. in the diastolic filling and the systolic contraction phase. This investigation shows, that gel injections are able to reduce maximal fibre stresses caused by an infarct. This

000015990 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000015990 653__ $$aMyocardial Infarction, Injection Therapy, Computational Cardiology, Meshless Method.

000015990 7112_ $$aCOMPDYN 2013 - 4th International Thematic Conference$$cIsland of Kos (GR)$$d2013-06-12 / 2013-06-14$$gCOMPDYN2013
000015990 720__ $$aSkatulla, S.$$iLegner, D.$$iRama, R.$$iMbewu, J.$$iReddy B., D.$$iDavis, N.$$iFranz, T.
000015990 8560_ $$ffischerc@itam.cas.cz
000015990 8564_ $$s877479$$uhttps://invenio.itam.cas.cz/record/15990/files/2071.pdf$$yOriginal version of the author's contribution as presented on CD, section: SC-MS 06 COMPUTATIONAL MODELING OF CARDIOVASCULAR DISEASES
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000015990 962__ $$r15525
000015990 980__ $$aPAPER