000001690 001__ 1690
000001690 005__ 20141118153458.0
000001690 04107 $$acze
000001690 046__ $$k2007-05-14
000001690 100__ $$aPásek, M.
000001690 24500 $$aUSE OF QUANTITATIVE MODEL TO ASSESS THE FRACTIONAL AREA OF T-TUBULAR MEMBRANE IN VENTRICULAR CARDIOMYOCYTE

000001690 24630 $$n13$$pEngineering Mechanics 2007
000001690 260__ $$bInstitute of Thermomechanics AS CR, v.v.i., Prague
000001690 506__ $$arestricted
000001690 520__ $$2eng$$aThe transverse (T-) tubules of cardiac ventricular myocytes create a complex network of membrane invaginations. Many of the key proteins involved in excitation-contraction coupling appear to be located predominantly at the Ttubule membrane. Despite their importance, the fraction of cell membrane within the T-tubules remains unclear: for example, measurement of cell capacitance following detubulation in rat cardiomyocytes suggests ~32%, whereas optical measurements suggest up to ~65%. We have therefore investigated the factors that may account for this discrepancy. Calculation of the combinations of Ttubule radius, length and density that produce T-tubular membrane fractions of 32% or 56% suggest that the true fraction is at the upper end of this range.

000001690 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000001690 653__ $$a

000001690 7112_ $$aEngineering Mechanics 2007$$cSvratka (CZ)$$d2007-05-14 / 2007-05-17$$gEM2007
000001690 720__ $$aPásek, M.$$iŠimurda, J.
000001690 8560_ $$ffischerc@itam.cas.cz
000001690 8564_ $$s314832$$uhttps://invenio.itam.cas.cz/record/1690/files/105-Pasek-PT.pdf$$y
             Original version of the author's contribution as presented on CD, .
            
000001690 962__ $$r1585
000001690 980__ $$aPAPER