000021402 001__ 21402
000021402 005__ 20170522124353.0
000021402 04107 $$aeng
000021402 046__ $$k2017-05-15
000021402 100__ $$aPásek, M.
000021402 24500 $$aA MODIFIED MATHEMATICAL MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE INCORPORATING SEPARATE T-TUBULAR AND SURFACE DYADS AND SUBMEMBRANE SPACES

000021402 24630 $$n23.$$pEngineering Mechanics 2017
000021402 260__ $$bBrno University of Technology, Institute of Solid Mechanics, Mechatronics and Biomechanics, Brno
000021402 506__ $$arestricted
000021402 520__ $$2eng$$aIntracellular Ca2+ load and Ca2+ transient are considerably dependent on distribution of sarcolemmal Ca2+ pump and Na+-Ca2+ exchanger between the t-tubular and surface membranes in the presence of separate dyadic and subsarcolemmal spaces in rat ventricular cell model. To explore analogical phenomenon in human, we modified our previously published model of human ventricular myocyte. When the t-tubular fractions of Na+-Ca2+ exchanger and of sarcolemmal Ca2+ pump were increased to the newly proposed value of 0.95 in the modified model, the following changes were observed at 1 Hz steady-state stimulation: a shortening of the action potential duration at 90 % repolarisation by 6 % and an increase of the cytosolic Ca2+ transient by 22 %. Further analysis revealed a critical role of Ca 2+ concentration changes in the subsarcolemmal spaces and consequent change in cellular Ca2+ cycling in this effect.

000021402 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000021402 653__ $$aHuman ventricular cell model, T-tubules, Dyads, Subsarcolemmal spaces, Calcium cycling.

000021402 7112_ $$aEngineering Mechanics 2017$$cSvratka, CZ$$d2017-05-15 / 2017-05-18$$gEM2017
000021402 720__ $$aPásek, M.$$iChristé, G.$$iBébarová, M.
000021402 8560_ $$ffischerc@itam.cas.cz
000021402 8564_ $$s843667$$uhttps://invenio.itam.cas.cz/record/21402/files/0750.pdf$$yOriginal version of the author's contribution in proceedings, page 750, section BIO.
000021402 962__ $$r21225
000021402 980__ $$aPAPER