000022694 001__ 22694
000022694 005__ 20220110134521.0
000022694 04107 $$aeng
000022694 046__ $$k2018-05-14
000022694 100__ $$aBansod, Y.D.
000022694 24500 $$aBendo-tensegrity model simulates compression test of animal cell

000022694 24630 $$n24.$$pEngineering Mechanics 2018
000022694 260__ $$bInstitute of Theoretical and Applied Mechanics of the Cech Academy of Sciences, Prague
000022694 506__ $$arestricted
000022694 520__ $$2eng$$aA hybrid model of suspended animal cell proposed earlier, with a bendo-tensegrity structure mimicking cytoskeleton, is applied to simulate the global response of the cell under compression and to describe mechanical behaviour of its components. The Finite Element model incorporates Microtubules, Actin Filaments, Intermediate Filaments, nucleus, cytoplasm, and Cell Membrane, all of them with realistic geometrical and material parameters. The unique features of this structural model keep fundamental principles governing cell behaviour, such as interaction between the cytoskeletal components redistributing the prestress of actin filaments throughout all the structure. The force-deformation curve from the simulated compression test with microplates is validated by comparison with the experimental response from literature. The model enables us to investigate the mechanical role of individual celular and cytoskeletal components in intracellular force propagation by means of changing their numbers or parameters. As quantitative characterization of nucleus deformation may be hypothetically decisive for mechanotransduction, the model aims at better understanding of how cellular processes are mechanically controlled.

000022694 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000022694 653__ $$acell mechanics, cytoskeleton, bendo-tensegrity model, compression test simulation

000022694 7112_ $$aEngineering Mechanics 2018$$cSvratka, CZ$$d2018-05-14 / 2018-05-17$$gEM2018
000022694 720__ $$aBansod, Y.D.$$iJakka Veera, V.S.V.P.$$iBurša, J.
000022694 8560_ $$ffischerc@itam.cas.cz
000022694 8564_ $$s874129$$uhttps://invenio.itam.cas.cz/record/22694/files/045.pdf$$yOriginal version of the author's contribution in proceedings, page , section BIO.
000022694 962__ $$r21225
000022694 980__ $$aPAPER