000022813 001__ 22813
000022813 005__ 20220110134528.0
000022813 04107 $$aeng
000022813 046__ $$k2018-05-14
000022813 100__ $$aMacháček, O.
000022813 24500 $$aMicro-fluidic system with grooved pole pieces of magnetic circuit

000022813 24630 $$n24.$$pEngineering Mechanics 2018
000022813 260__ $$bInstitute of Theoretical and Applied Mechanics of the Cech Academy of Sciences, Prague
000022813 506__ $$arestricted
000022813 520__ $$2eng$$aMicro-fluidic systems are used in approximately 30 years for detect or separate biological molecules which are contain in a biological medium (blood, serum, etc.). The technique of separation is based on magnetic force acting on the magnetic particles which are added to the medium. One way to increase separation efficiency is to optimize the magnetic circuit. Two versions of magnetic circuit for the micro-fluidic system are designed, tested and compared in this study. The first of them has solid pole pieces (without grooves), the second one is provided with grooves which are oriented perpendicular to the direction of a fluid flow through the system. A suitable geometry of the grooves was chosen using a FEM model which is verified by measurement. Hypothesis that the grooved pole pieces ensure higher amount of captured particles in the system in comparison with the case of solid pole pieces was confirmed. But, the comparison of the captured particles amount was made just visually. Therefore, the amount of particles which are washout during a flow test should be evaluated by more quantifiable method in future study, for example using Beer-Lambert law.

000022813 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000022813 653__ $$amicro-fluidic system, immunoassay, magnetic circuit, grooved pole pieces

000022813 7112_ $$aEngineering Mechanics 2018$$cSvratka, CZ$$d2018-05-14 / 2018-05-17$$gEM2018
000022813 720__ $$aMacháček, O.$$iet, al.
000022813 8560_ $$ffischerc@itam.cas.cz
000022813 8564_ $$s2585163$$uhttps://invenio.itam.cas.cz/record/22813/files/521.pdf$$yOriginal version of the author's contribution in proceedings, page , section FLU.
000022813 962__ $$r21225
000022813 980__ $$aPAPER