000022860 001__ 22860
000022860 005__ 20220110134530.0
000022860 04107 $$aeng
000022860 046__ $$k2018-05-14
000022860 100__ $$aRebenda, D.
000022860 24500 $$aEffect of hyaluronic acid on friction of articular cartilage

000022860 24630 $$n24.$$pEngineering Mechanics 2018
000022860 260__ $$bInstitute of Theoretical and Applied Mechanics of the Cech Academy of Sciences, Prague
000022860 506__ $$arestricted
000022860 520__ $$2eng$$aIntra-articular injections of hyaluronic acid based solutions are gaining popularity as a treatment option for non-operative management of patients with degenerative joint diseases. Although there is a plenty of evidence for lowering of friction in large human joints by exogenous hyaluronic acid, the physical phenomenon standing behind these results has not been clarified yet. This leads to large dispersion in effectiveness and duration in action of viscosupplementation as a treatment for osteoarthritis and; subsequently, to disparity between the view of practitioners and recent procedures questioning or disregarding the efficiency of hyaluronic acid injections. In this study, the changes in friction between intact porcine cartilage and glass plate during reciprocating sliding tests were observed to better understand interaction between hyaluronic acid and synovial fluid components. Contact was lubricated with protein solutions both with and without addition of hyaluronic acid. The effectiveness of proteins and influence of hyaluronic acid on friction are discussed.

000022860 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000022860 653__ $$aarticular cartilage, synovial fluid, friction, hyaluronic acid, viscosupplemenatation

000022860 7112_ $$aEngineering Mechanics 2018$$cSvratka, CZ$$d2018-05-14 / 2018-05-17$$gEM2018
000022860 720__ $$aRebenda, D.$$iet, al.
000022860 8560_ $$ffischerc@itam.cas.cz
000022860 8564_ $$s574933$$uhttps://invenio.itam.cas.cz/record/22860/files/709.pdf$$yOriginal version of the author's contribution in proceedings, page , section BIO.
000022860 962__ $$r21225
000022860 980__ $$aPAPER