000004110 001__ 4110
000004110 005__ 20141118153335.0
000004110 04107 $$acze
000004110 046__ $$k2004-05-10
000004110 100__ $$aPásek, M.
000004110 24500 $$aIonic concentration changes in the tubular system of rat ventricular cardiac cell model

000004110 24630 $$n10.$$pEngineering Mechanics 2004
000004110 260__ $$bInstitute of Thermomechanics AS CR, v.v.i., Prague
000004110 506__ $$arestricted
000004110 520__ $$2eng$$aWe present a design of a model of rat ventricular cardiomyocyte with transverse-axial tubular system and the results of the first simulations of tubular ionic concentration changes at different stimulation rates. The morphology of tubular system and the distribution of ionic channels in tubular membrane were described to meet the recent data of Soeller and Cannell (1999) and of Orchard's group in Leeds. Exploration of activity-dependent changes in tubular ionic concentrations revealed an increase in relative Ca2+ depletion from 7.3 % to 14 % when increasing the stimulation frequency from 1 Hz to 5 Hz. Meanwhile, relative K+ accumulation decreased from 4.3 % to 3 %. These effects led to a limitation of intracellular Ca2+ overload.

000004110 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000004110 653__ $$a

000004110 7112_ $$aEngineering Mechanics 2004$$cSvratka (CZ)$$d2004-05-10 / 2004-05-13$$gEM2004
000004110 720__ $$aPásek, M.$$iŠimurda, J.$$iChristé, G.
000004110 8560_ $$ffischerc@itam.cas.cz
000004110 8564_ $$s551201$$uhttps://invenio.itam.cas.cz/record/4110/files/T-Pasek-Michal.pdf$$y
             Original version of the author's contribution as presented on CD, .
            
000004110 962__ $$r4009
000004110 980__ $$aPAPER