000004949 001__ 4949
000004949 005__ 20141119144607.0
000004949 04107 $$aeng
000004949 046__ $$k2002-06-02
000004949 100__ $$aSilva, Emilio C. C. M.
000004949 24500 $$aA BIO-CHEMO-MECHANICS APPROACH TO BONE RESORPTION AND FRACTURE

000004949 24630 $$n15.$$pProceedings of the 15th ASCE Engineering Mechanics Division Conference
000004949 260__ $$bColumbia University in the City of New York
000004949 506__ $$arestricted
000004949 520__ $$2eng$$aIn this paper, we develop a biochemomechanics theory, which allows the integration of a biological process orchestrated by cells into a chemomechanics framework. The derivation is based on first principles of thermodynamics and is developed around the modeling of bone resorption. We show that the driving force of the process involves three quantities: a biologically generated chemical potential, developed by the cell on the solid surface; the chemical potential of the solid mineral; and, finally, the strain energy stored in the solid phase. Orders of magnitude of these three quantities are evaluated using existing data. It is shown that the average strain energy is some orders of magnitude smaller than the BGP. However, in the immediate surrounding of cracks, the strain energy increases due to stress concentrations to 10-50% of the BGP. In the course of remodeling events, we propose that this chemomechanical coupling is a nonrandom remodeling stimulus, helping repair damage in bone, which at the same time reduces the risk of crack propagation.

000004949 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000004949 653__ $$aBiochemomechanics, Resorption, Fracture, Biologically Generated Potential

000004949 7112_ $$a15th ASCE Engineering Mechanics Division Conference$$cNew York (US)$$d2002-06-02 / 2002-06-05$$gEM2002
000004949 720__ $$aSilva, Emilio C. C. M.$$iUlm, Franz-Josef
000004949 8560_ $$ffischerc@itam.cas.cz
000004949 8564_ $$s547947$$uhttps://invenio.itam.cas.cz/record/4949/files/597.pdf$$yOriginal version of the author's contribution as presented on CD, .
000004949 962__ $$r4594
000004949 980__ $$aPAPER