000000906 001__ 906
000000906 005__ 20141118153511.0
000000906 04107 $$acze
000000906 046__ $$k2002-05-13
000000906 100__ $$aPásek, M.
000000906 24500 $$aQUANTITATIVE MODELLING OF EFFECT OF TRANSVERSE-AXIAL TUBULAR SYSTEM ON ELECTRICAL ACTIVITY OF CARDIAC CELLS: DEVELOPMENT OF MODEL
000000906 24630 $$n8.$$pEngineering Mechanics 2002
000000906 260__ $$bInstitute of Mechanics and Solids, FME, TU Brno
000000906 506__ $$arestricted
000000906 520__ $$2cze$$aAbstrakt: The transverse-axial tubular system (TAT-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. As suggested in many recent experimental works, it could have a significant effect on cardiac cell function induced by the accumulation or the depletion of ions in restricted tubular space.  In our previous work [27J, the basic properties of TAT-system were formulated and preliminary simulations characterizing its effect on cellular electrical activity realised.  In this article, we describe the design of a more complex model of ventricular myocyte based mostly on data from guinea pig. The model integrates the description of electrical activity of surface and tubular membranes with the detailed description of mechanisms controlling the intracellular and tubular ion concentrations.
000000906 520__ $$2eng$$aAbstract: The transverse-axial tubular system (TAT-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. As suggested in many recent experimental works, it could have a significant effect on cardiac cell function induced by the accumulation or the depletion of ions in restricted tubular space.  In our previous work [27J, the basic properties of TAT-system were formulated and preliminary simulations characterizing its effect on cellular electrical activity realised.  In this article, we describe the design of a more complex model of ventricular myocyte based mostly on data from guinea pig. The model integrates the description of electrical activity of surface and tubular membranes with the detailed description of mechanisms controlling the intracellular and tubular ion concentrations.
000000906 540__ $$aText je chráněný podle autorského zákona č. 121/2000 Sb.
000000906 7112_ $$aEngineering Mechanics 2002$$cSvratka (CZ)$$d2002-05-13 / 2002-05-16$$gEM2002
000000906 720__ $$aPásek, M.$$iŠimurda, J.$$iChristé, G.
000000906 8560_ $$ffischerc@itam.cas.cz
000000906 8564_ $$s281616$$uhttps://invenio.itam.cas.cz/record/906/files/Pasek.pdf$$y
             Original version of the author's contribution as presented on CD, .
            
000000906 962__ $$r451
000000906 980__ $$aPAPER