Contributions of ECM Constituents to Arterial Wall Mechanics

Abstract eng:
Considering the organization and engagement behavior of extracellular matrix (ECM) constituents in the arterial wall, here we proposed a new constitutive model of ECM mechanics that consists of medial elastin, medial collagen, and adventitial collagen, to incorporate the layer-specific distribution of elastin and collagen fiber orientations and the sequential fiber engagement in arterial mechanics. Planar biaxial tensile testing method was used to characterize the orthotropic and hyperelastic behavior of porcine thoracic aorta. Fiber distribution functions obtained previously [1] were incorporated into the constitutive model. Considering the sequential engagement of ECM constituents in arterial mechanics, a collagen recruitment function was incorporated into the model to capture the delayed engagement of adventitial collagen. A freely jointed chain model was used to capture the mechanical behavior of elastin and collagen at the fiber level. The tissue-level ECM mechanics was obtained by incorporating fiber distribution, engagement, and elastin and collagen content.

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