Assessment of material and geometrical parameters influence on IOP changes after injections

Abstract eng:
In this work we present mathematical models for the intraocular pressure (IOP) simulations after intravitreal injections. We developed models of IOP changes for the ellipsoidal form of the eye, considering its coat to be transversally isotropic. We simulated the relationship between the IOP and the inner volume of the eye with the help of the refined theory of thin shells and using Comsol Multiphysics FEM package. Global sensitivity analysis was performed to quantify the relative importance of material and geometrical parameters of the eyeball on the IOP elevation. The results showed that the axial length and elastic modulus affect the IOP changes significantly and the effects of Poisson’s ratios are almost neglectable. However, when we introduced the relative volume, it became the most influential parameter: the magnitude of its effect was 50% of the total response.

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