Flow of blood cells in complex geometry

Abstract eng:
A three-dimensional computational tool for simulating the flow of blood cells through geometries of arbitrary complexity is presented. Examples of complex geometries include, but are not limited to, micro-fluidic channels and networks, stenosed blood vessels, cell and particulate sorting devices, and complex micro-vascular networks. The computational tool is designed to span the entire spectrum of scales typically encountered in microcirculatory blood flow, thus enabling the direct simulation of physiologically realistic problems. The three- dimensional unsteady Stokes equations are solved numerically in conjunction with two separate types of immersed boundary methods; a sharp- interface method is used to simulate stationary and moving rigid boundaries, while a front-tracking method is used to simulation the motion of highly deformable blood cells. The resulting tool provides a fast, stable, and accurate platform for simulating highly complex problems involving cellular motion in a wide range of complex geometries.

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