Catch bonds and mechano-sensitivity of acto-myosin filament networks

Abstract eng:
A number of biological filament network are able to generate contratile forces and deformation over large regions with the help of H§)t(; proteins, allowing filament to slide along one-another. A particularity of such networks, such as the acto-myosin network in adherent cells, is that the assembly display a mechano-sensitive behavior, that is, contraction can be tuned by the effect of external forces and stiffness. This paper presents a mechanistic model, based on the concept of catch bond, that explains how such responses can be observed at fairly large scales. Particular examples pertaining to the contractile mechanics of adherent cells are presented.

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