Carotid wall stress analysis based on in vivo intravascular optical coherence tomography imaging

Abstract eng:
Biomechanical properties of arteries are strongly related to vascular disease. Theoretical analysis or numerical simulationbased on simplified models can’t provide accurate information about the deformation of the blood vessel. In this paper, high resolution intravascular optical coherence tomography (IVOCT) imaging is integrated with numerical simulation to study the transmural stress distribution of arteries. 3D structure and flow profile was obtained through imaging of a porcine carotid artery in vivo. 3D carotid model was created based on the images and the blood flow velocity was incorporated for simulation. Preliminary results show that the Von Mises stress distribution across the vascular wall thickness is circumferentially uniform. This is the first carotid wall stress analysis based on in vivo IVOCT imaging. It may pave the road for vascular mechanics studies by integrating high resolution imaging and numerical simulation, which will provide important information for the study, diagnosis and treatment of vascular diseases.

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