Design Study of Anatomically Shaped Latticed Scaffolds for the Bone Tissue Recovery

Abstract eng:
The current major scaffold design concepts for bone tissue recovery are characterized by labyrinthine design. Their main shortcomings are low level of permeability for new growing tissue, poor design adaptability in regard to particular anatomy and required biomechanical conditions during recovery, as well as very demanding post processing after free form fabrication. In contrast to the most of the existing solutions, latticed scaffold design does not try to imitate the trabecular structure and rejects the labyrinthine concept. It is characterized by simple 3D latticed support structure, which provides a high level of permeability for the new growing tissue cells, and in the same time a proper level of bio-adhesiveness. In addition, its design is easy to manage in order to make it follow the particular anatomical shape and at the same time provide the required elastic properties and structural strength. The paper presents a part of design concept proving process, which is related to stress analysis of the anatomically shaped lattice scaffold design. The aim of the analysis was to identify functional relation between design parameters and elastic properties of the scaffold. The established relations are crucial for getting optimal values of elastic properties of scaffold that are required in a specific trauma-fixation case. The design study shown in the paper was done for the case of lattice scaffold anatomically shaped to the upper part of proximal diaphyseal trauma of rabbit tibia. Design parameters which were altered within the design study were lattice’s struts cross-sectional area, density of the struts and angle of the struts intersection. The analysis showed that structural flexibility of latticelike scaffold may easily be changed through modification of three selected design parameters. In this way, it is confirmed that the proposed type of scaffold has an important capability to adapt its elastic properties to the required values, while being able to keep its great permeability and geometrical consistency to the particular anatomy of trauma region.

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