Computational Modeling of Transport of Cells and Particles in Small Blood Vessels

Abstract eng:
Computational modeling of convective transport within biological systems is still one of the most challenging tasks in computational mechanics. Here, we present our computational approach of the solidfluid interaction based on a strong coupling method and remeshing procedure [1]-[2]. We have found that this procedure is the most robust, reliable and accurate with respect to other approaches available in literature. The models also include interactions among moving bodies and also with rigid and deformable walls. The interactions can be repulsive, attractive, deterministic and stochastic. The models include both 2D and 3D conditions. Besides several verification examples, the most of the applications are related to modeling motion of cells, micro and nanoparticles within small domains (channels, chips for cancer cell separation, capillaries with narrowing). Results provide insight into mechanical and biochemical phenomena occurring in complex biological environment.

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