Plaque Formation Modeling - From Animal To Human Studies

Abstract eng:
Atherosclerosis is a progressive disease characterized by inflammation, monocyte-macrophage migration, and lipid accumulation in the vascular wall. In this study, we analysed animal pig model as well as clinical data from CNR Pisa studies, within the ARTreat Project research activities (www.artreat.kg.ac.rs). The experimental protocol is implemented on 6 pigs with a high-lipid subjected to diet for 8 weeks. The 3D blood flow is governed by the Navier-Stokes equations, together with the continuity equation. Mass transfer within the blood lumen and through the arterial wall is coupled with the blood flow, and is modeled by the convection-diffusion equation. The LDL transport in lumen of the vessel is described by Kedem-Katchalsky equations. The inflammatory process is modeled using three additional reaction-diffusion partial differential equations. Matching the IVUS and histological animal data is performed using 3D histological image reconstruction and 3D deformation models of elastic body. Good comparison for pigs was achieved for lesion area size, foam cells lipids and CXCR4 signals. For human data we investigated the volume plaque progression. Four patients for coronary artery disease were analysed. Matching of plaque location and progression in time between experimental and computer model shows a potential benefit for future prediction of this vascular decease using computer simulation.

• Export as: BibTeX | MARC | MARCXML | DC | EndNote | NLM | RefWorks
• Add to your basket