A NEW QUANTITATIVE DESCRIPTION OF INTRACELLULAR CA2+ DYNAMICS IN THE MODEL OF RAT VENTRICULAR MYOCYTE
Abstract eng: In this paper, a new description of intracellular Ca2+ dynamics in the model of rat ventricular cardiomyocyte is presented. The principal modifications based on the recently published data comprise: formulation of the function of peripheral dyads, incorporation of peripheral and tubular intracellular subspaces, reformulation of inactivation properties of surface of tubular ICa and description of the function of exogenous Ca2+ buffer in intracellular space. The modified model will be used to explore the activity induced ion-concentration changes in rat transverse-axial tubular system in a more detail and to investigate their effects on excitation – contraction coupling in ventricular cardiomyocytes.
Contributors:
Publisher:
Institute of Thermomechanics AS CR, v.v.i., Brno
Conference Title:
Conference Title:
Engineering Mechanics 2011
Conference Venue:
Svratka (CZ)
Conference Dates:
2011-05-09 / 2011-05-12
Rights:
Text je chráněný podle autorského zákona č. 121/2000 Sb.
Record appears in:
Record created 2014-10-24, last modified 2014-11-18
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