Intracellular Ca2+ load and Ca2+ transient are considerably dependent on distribution of sarcolemmal Ca2+ pump and Na+-Ca2+ exchanger between the t-tubular and surface me [...]

The inwardly rectifying potassium current IK1 is one of the principle ionic currents responsible for repolarization phase of mammalian action potentials (APs). To estimat [...]

We present a design of a model of rat ventricular cardiomyocyte with transverse-axial tubular system and the results of the first simulations of tubular ionic concentrati [...]

The paper presents biophysical characteristics of transient outward potassium current (IKto) obtained from experiments on isolated rat ventricular cardiomyocytes. Based o [...]

A novel quantitative model of a guin ea-pig ventricular myocyte has been designed with transverse-axial tubular system (TATS) included. This model displays long-term stab [...]

In this paper, a new description of intracellular Ca2+ dynamics in the model of rat ventricular cardiomyocyte is presented. The principal modifications based on the recen [...]

The transverse (T-) tubules of cardiac ventricular myocytes create a complex network of membrane invaginations. Many of the key proteins involved in excitation-contractio [...]

In this work, we present a new version of cardiac ventricular cell model incorporating the transverse - axial tubular system. The improvements include reformulated descri [...]

Abstrakt: The transverse-axial tubular system (TAT-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. As suggest [...]