USE OF QUANTITATIVE MODEL TO ASSESS THE FRACTIONAL AREA OF T-TUBULAR MEMBRANE IN VENTRICULAR CARDIOMYOCYTE

Abstract eng:
The transverse (T-) tubules of cardiac ventricular myocytes create a complex network of membrane invaginations. Many of the key proteins involved in excitation-contraction coupling appear to be located predominantly at the Ttubule membrane. Despite their importance, the fraction of cell membrane within the T-tubules remains unclear: for example, measurement of cell capacitance following detubulation in rat cardiomyocytes suggests ~32%, whereas optical measurements suggest up to ~65%. We have therefore investigated the factors that may account for this discrepancy. Calculation of the combinations of Ttubule radius, length and density that produce T-tubular membrane fractions of 32% or 56% suggest that the true fraction is at the upper end of this range.

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