Microcirculation of red blood cells for two major genetic diseases

Abstract eng:
Sickle Cell Anaemia and Hereditary Spherocytosis are genetic hematological disorders in which red blood cell rigidity is increased. These changes result in problems of RBC circulation in narrow capillaries and through the thin slits of splenic sinusoids - both situations where the RBCs may be subject to very strong deformations. Here, we first show that even in presence of oxygen most RBCs from sickle cell anemia patients have an impaired motion when submitted to a shear flow at low shear rate. We then observe the passage of sickle RBCs, spherocytes and healthy RBCs through slits mimicking interendothelial slits within the spleen. Their difference in terms of transit time, trapped cell ratio, lysis ratio and RBC recovery time are quantitatively determined.

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