A biomimetic microfluid assay for rapid screening of anti- inflammatory drugs (INVITED)

Abstract eng:
Almost all drugs recently developed in animal models to treat inflammatory disease have failed in clinical trials. There is therefore a significant need for rapid screening of anti-inflammatory drugs before they are tested for safety, efficacy and toxicity in expensive and time consuming large animal models and eventually human trials. We have developed and validated a novel biomimetic microfluidic assay (bMFA) that reproduces the entire leukocyte adhesion cascade in a physiologically realistic three-dimensional environment using human cells and allows for rapid screening of potential therapeutics. Protein Kinase C- delta (PKCS TAT) inhibitor represents a new class of anti-inflammatory drug and we have used bMFA to show the potentially therapeutic effects of this novel drug on human neutrophil-endothelial interactions.

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