Force-induced internalization of magnetic nanoparticles for drug delivery and cell tracking

Abstract eng:
We have systematically studied the use of applied magnetic force to facilitate the cellular internalization of magnetic nanoparticles. The magnetic nanoparticles have uniform core sizes and coated with phospholipid-PEG. We investigated the pathway of nanoparticle internalization into different cell types under an applied magnetic field and determined the dependence of cellular uptake on nanoparticle size and concentration, substrate stiffness, temperature, and changes of the cytoskeletal structure. Our results shed light on force-induced endocytosis of nanoparticles and provide a means to remotely control vascular permeability, thus having the potential to shift the paradigm of targeted drug delivery and open up new opportunities for the application of nanotherapeutics.

• Export as: BibTeX | MARC | MARCXML | DC | EndNote | NLM | RefWorks
• Add to your basket