Mechanics of stem cell myogenesis

Abstract eng:
Myo genesis of stem cells is the process of their conversion into skeletal muscle cells. The mechanical factors play a key role in this process, and they can be used to maximize the stem cell myogenic output. Our goal here is a better understanding and use of this effect. We interpret stem cell myogenesis as a progression through several key stages where each of them is characterized by the expression of specific proteins (myogenic factors). The cell stage-to-stage progression is affected by the magnitude and time course of the applied strain through the intracellular signalling. The model of this mechanism is described in terms of nonlinear ODEs and applied to the analysis of stem cell myogenesis under the action of cyclic uniaxial strain The model parameters are adjusted based on a parallel experiment, and the results are used for the optimization of the amplitude, frequency, and duration of the applied strain.

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