The role of line tension on budding formation induced by diffusion of proteins on lipid bilayer

Abstract eng:
We investigate the effects of line tension at the lipid-protein domain interface on membrane budding formation which is assumed to be induced by surface diffusion of the trans-membrane proteins. The theoretical model for the mechanics of membrane shape transformation is described by a modified formulation of the Helfrich model in order to accommodate any nonlinear response of the membrane due to the diffusion of the trans-membrane proteins. The resulting shape equation is numerically solved for Non-Monge or general membrane surface representation. Our results show that line tension at the domain interface makes a significant contribution on a spherical-shape-like budding formation on weakly curved or flat lipid membrane. We show numerically that increasing the line tension facilitates the reduction of the interface diameter between the flat membrane and generated spherical bud, thus increasing the potential to pinch off the bud. Full details can be found in [1].

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